Evento

08 Abril | OPEN SCIENCE Seminar | Dra. Monica Sousa “The Power of exceptions- How to regenerate the spinal cord in mammals”

Fecha: 08/04/2025
Lugar: Auditorio A-103, Avda. El Cóndor 844, Campus Ciudad Universitaria, Huechuraba
Horario: 15:30 -17:00
Organizador: CCTE Ciencia & Vida - USS

We invite you to participate in the Open Science Seminar led by Dra. Monica Sousa del Instituto de Investigaçao e Inovaçao em Saúde [i3S], Portugal.
This event will take place on April 8th, from 3:30 to 5:00 PM, in Auditorio A-103, Avda. El Cóndor 844, Campus Ciudad Universitaria.

Biosketch: Dr. Monica M Sousa graduated in Biochemistry and holds a PhD in Biomedical Sciences from the University of Porto. During her PhD she studied the biology of an aggregation-prone protein that induces axon degeneration. As a postdoctoral fellow, Monica worked at Columbia University- New York, where she studied signaling cascades mediating neurodegeneration caused by amyloid fibrils. Since 2008, Monica leads the Nerve Regeneration group at the i3S, University of Porto. Her group is focused on characterizing pathways that control axon growth during development, and regeneration following injury. In this respect, the Sousa group has recently found that the spiny mouse is a unique exception to mammals being able to spontaneously regenerate the spinal cord.

Summary: Regeneration of the adult mammalian central nervous system (CNS)  is abortive, resulting in inability to recover function after CNS lesion, including spinal cord injury. We have recently identified the spiny mouse (Acomys) as the sole known exception to other mammals, as it is capable of spontaneous and fast restoration of function after complete spinal cord transection. In this seminar, I will discuss our work aimed at identifying the mechanisms enabling the outstanding regeneration of the spiny mouse spinal cord, going from genomics to transcriptiomics and the evolution of regenerative ability.

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