:root .roi-expression-launcher {
  display: grid;
  gap: 10px;
  margin-top: 14px;
  padding: 12px;
  border: 1px solid #31433a;
  border-radius: 10px;
  background: linear-gradient(155deg, rgba(21, 38, 32, 0.96), rgba(13, 19, 16, 0.98));
  box-shadow: inset 0 1px rgba(255, 255, 255, 0.025);
}

:root .roi-expression-launcher-heading {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 8px;
}

:root .roi-expression-launcher-heading > span,
:root .roi-expression-wide-control-heading {
  display: inline-flex;
  min-width: 0;
  align-items: center;
  gap: 7px;
  color: #e9f7ef;
}

:root .roi-expression-launcher-heading svg,
:root .roi-expression-wide-control-heading svg {
  flex: 0 0 auto;
  color: #65d1a8;
}

:root .roi-expression-launcher-heading strong { font-size: 11px; }
:root .roi-expression-launcher-heading small { color: #88aa9b; font-size: 8px; text-transform: uppercase; }
:root .roi-expression-launcher > p { margin: 0; color: #91a198; font-size: 9px; line-height: 1.45; }

:root .roi-expression-gene-selector {
  position: relative;
  display: grid;
  gap: 6px;
  min-width: 0;
}

:root .roi-expression-gene-search {
  display: grid;
  grid-template-columns: auto minmax(0, 1fr) auto;
  align-items: center;
  gap: 6px;
  min-height: 34px;
  padding: 0 9px;
  border: 1px solid #35463d;
  border-radius: 7px;
  color: #7f9187;
  background: #0c120f;
}

:root .roi-expression-gene-search:focus-within {
  border-color: #43aa86;
  box-shadow: 0 0 0 2px rgba(67, 170, 134, 0.16);
}

:root .roi-expression-gene-search input {
  width: 100%;
  min-width: 0;
  height: 32px;
  padding: 0;
  border: 0;
  outline: 0;
  color: #edf5ef;
  background: transparent;
  font: inherit;
  font-size: 11px;
}

:root .roi-expression-gene-search input:disabled { cursor: not-allowed; opacity: 0.55; }

:root .roi-expression-gene-results {
  position: absolute;
  z-index: 30;
  top: 40px;
  right: 0;
  left: 0;
  display: grid;
  max-height: 210px;
  overflow: auto;
  padding: 5px;
  border: 1px solid #3d5047;
  border-radius: 8px;
  background: #101713;
  box-shadow: 0 12px 30px rgba(0, 0, 0, 0.42);
}

:root .roi-expression-gene-results button {
  display: flex;
  width: 100%;
  min-height: 32px;
  align-items: center;
  justify-content: space-between;
  gap: 8px;
  padding: 5px 7px;
  border: 0;
  border-radius: 5px;
  color: #e9f3ec;
  background: transparent;
  cursor: pointer;
  text-align: left;
}

:root .roi-expression-gene-results button:hover,
:root .roi-expression-gene-results button:focus-visible { outline: none; background: #1b332a; }
:root .roi-expression-gene-results button small { overflow: hidden; color: #82938a; font-size: 9px; text-overflow: ellipsis; }
:root .roi-expression-gene-results .empty { margin: 6px; }

:root .roi-expression-gene-chips {
  display: flex;
  flex-wrap: wrap;
  gap: 5px;
  min-height: 25px;
}

:root .roi-expression-gene-chips > span {
  display: inline-flex;
  align-items: center;
  gap: 3px;
  min-height: 25px;
  padding-left: 7px;
  border: 1px solid #37604f;
  border-radius: 6px;
  color: #d9f6e8;
  background: rgba(28, 83, 65, 0.42);
  font-size: 10px;
  font-weight: 700;
}

:root .roi-expression-gene-chips button {
  display: grid;
  width: 24px;
  height: 23px;
  place-items: center;
  border: 0;
  border-left: 1px solid rgba(104, 171, 145, 0.28);
  color: #b8d9ca;
  background: transparent;
  cursor: pointer;
}

:root .roi-expression-gene-chips button:hover:not(:disabled),
:root .roi-expression-gene-chips button:focus-visible { color: #fff; background: rgba(113, 198, 165, 0.16); outline: none; }
:root .roi-expression-gene-chips button:disabled { cursor: not-allowed; opacity: 0.35; }
:root .roi-expression-gene-chips > small { align-self: center; color: #85958b; font-size: 10px; line-height: 1.4; }

:root .roi-expression-launcher-normalization,
:root .roi-expression-wide-controls > label {
  display: grid;
  gap: 5px;
  color: #b8c8bf;
  font-size: 10px;
  font-weight: 700;
}

:root .roi-expression-launcher select,
:root .roi-expression-wide-controls select {
  width: 100%;
  min-height: 34px;
  padding: 0 8px;
  border: 1px solid #35463d;
  border-radius: 7px;
  outline: none;
  color: #e8f2ec;
  background: #101713;
  font-size: 10px;
}

:root .roi-expression-launcher select:focus-visible,
:root .roi-expression-wide-controls select:focus-visible { border-color: #52bc94; box-shadow: 0 0 0 2px rgba(82, 188, 148, 0.17); }

:root .roi-expression-open-workspace {
  display: inline-flex;
  min-height: 38px;
  align-items: center;
  justify-content: center;
  gap: 7px;
  padding: 0 10px;
  border: 1px solid #39a17d;
  border-radius: 7px;
  color: #effff8;
  background: #176249;
  font-size: 10px;
  font-weight: 760;
  cursor: pointer;
}

:root .roi-expression-open-workspace:hover:not(:disabled) { background: #1b7757; }
:root .roi-expression-open-workspace:focus-visible { outline: 3px solid #77d5b2; outline-offset: 2px; }
:root .roi-expression-open-workspace:disabled { cursor: not-allowed; opacity: 0.45; }
:root .roi-expression-launch-error { padding: 7px 8px; border: 1px solid #754242; border-radius: 6px; color: #ffd0d0 !important; background: rgba(83, 27, 27, 0.28); }

:root .roi-expression-wide-workspace {
  width: 100%;
  min-width: 0;
  height: 100dvh;
  min-height: 560px;
  overflow: hidden;
  color: #e8eee9;
  background: #09100d;
}

:root .roi-expression-wide-workspace .roi-workspace-header { position: relative; z-index: 20; }
:root .roi-expression-wide-workspace .roi-workspace-header h1 { max-width: min(58vw, 820px); overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }

:root .roi-expression-wide-summary {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 1px;
  min-height: 64px;
  border-bottom: 1px solid #28352f;
  background: #1b2822;
}

:root .roi-expression-wide-summary > span {
  display: grid;
  align-content: center;
  gap: 3px;
  padding: 8px 18px;
  border-right: 1px solid #2b3932;
}

:root .roi-expression-wide-summary strong { overflow: hidden; color: #eaf8ef; font-size: 16px; text-overflow: ellipsis; white-space: nowrap; }
:root .roi-expression-wide-summary small { color: #8fa097; font-size: 10px; text-transform: uppercase; }

:root .roi-expression-wide-main {
  display: grid;
  grid-template-columns: 238px minmax(0, 1fr);
  min-height: 0;
  min-width: 0;
  height: auto;
}

:root .roi-expression-wide-controls {
  position: relative;
  z-index: 10;
  display: grid;
  align-content: start;
  gap: 16px;
  min-width: 0;
  overflow: auto;
  padding: 18px 16px;
  border-right: 1px solid #2a3831;
  background: #101914;
}

:root .roi-expression-wide-control-heading strong { font-size: 12px; }
:root .roi-expression-wide-controls > p { margin: 0; color: #a4b5aa; font-size: 11px; line-height: 1.6; }
:root .roi-expression-wide-controls > label { font-size: 11px; }
:root .roi-expression-wide-controls select { min-width: 0; min-height: 38px; font-size: 11px; }

:root .roi-expression-wide-plot-switch,
:root .roi-expression-wide-heatmap-switch {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 4px;
  padding: 3px;
  border: 1px solid #2e3b34;
  border-radius: 7px;
  background: rgba(6, 11, 9, 0.56);
}

:root .roi-expression-wide-heatmap-switch { grid-template-columns: 1fr 1fr; }
:root .roi-expression-wide-plot-switch button,
:root .roi-expression-wide-heatmap-switch button {
  min-width: 0;
  min-height: 36px;
  padding: 4px 6px;
  border: 0;
  border-radius: 5px;
  color: #b4c4b9;
  background: transparent;
  font-size: 11px;
  font-weight: 700;
  cursor: pointer;
}

:root .roi-expression-wide-plot-switch button.active,
:root .roi-expression-wide-heatmap-switch button.active { color: #effff8; background: #245b49; box-shadow: inset 0 0 0 1px #3c8e70; }
:root .roi-expression-wide-plot-switch button:focus-visible,
:root .roi-expression-wide-heatmap-switch button:focus-visible { outline: 3px solid #77d5b2; outline-offset: 2px; }

:root .roi-expression-wide-gene-editor { display: grid; gap: 8px; min-width: 0; }
:root .roi-expression-wide-gene-editor > strong { color: #c9d9d0; font-size: 11px; }

:root .roi-expression-wide-results {
  display: grid;
  align-content: start;
  gap: 14px;
  min-width: 0;
  overflow: auto;
  min-height: 0;
  padding: clamp(16px, 2vw, 28px);
  background: #0c1310;
  grid-auto-rows: max-content;
}

:root .roi-expression-wide-chart {
  min-width: 0;
  max-width: 100%;
  overflow-x: auto;
  overflow-y: hidden;
  border: 1px solid #d9e0db;
  border-radius: 8px;
  color: #17231e;
  background: #fff;
  box-shadow: 0 10px 30px rgba(0, 0, 0, 0.2);
  min-height: min-content;
}

:root .roi-expression-wide-chart:focus-visible,
:root .roi-expression-wide-table:focus-visible { outline: 3px solid #77d5b2; outline-offset: 3px; }
:root .roi-expression-wide-chart .roi-expression-comparison-svg {
  display: block;
  width: 100%;
  min-width: 820px;
  max-width: none;
  height: auto;
  max-height: none;
  margin: 0;
  background: #fff;
}

:root .roi-expression-chart-data {
  min-width: 0;
  border: 1px solid #2e4035;
  border-radius: 8px;
  background: #101a14;
}

:root .roi-expression-chart-data > summary {
  padding: 13px 14px;
  color: #d6e5dc;
  font-size: 12px;
  font-weight: 600;
  cursor: pointer;
}

:root .roi-expression-chart-data > summary::marker { color: #83aa99; }
:root .roi-expression-chart-data > summary span { margin-left: 12px; color: #9caea2; font-size: 11px; font-weight: 400; }
:root .roi-expression-chart-data > summary:focus-visible { outline: 2px solid #77d5b2; outline-offset: 3px; border-radius: 6px; }
:root .roi-expression-chart-data[open] > summary { border-bottom: 1px solid #2e4035; }
:root .roi-expression-chart-data .roi-expression-wide-table { border: 0; border-radius: 0 0 8px 8px; }

:root .roi-expression-wide-table {
  max-width: 100%;
  overflow: auto;
  border: 1px solid #33413a;
  border-radius: 10px;
  background: #111915;
}

:root .roi-expression-wide-table table { width: 100%; min-width: 680px; border-collapse: collapse; color: #dbe7e0; font-size: 11px; font-variant-numeric: tabular-nums; }
:root .roi-expression-wide-table th,
:root .roi-expression-wide-table td { padding: 9px 12px; border-right: 1px solid #334039; border-bottom: 1px solid #334039; text-align: right; white-space: nowrap; }
:root .roi-expression-wide-table th:first-child,
:root .roi-expression-wide-table td:first-child,
:root .roi-expression-wide-table td:nth-child(2) { text-align: left; }
:root .roi-expression-wide-table thead th { position: sticky; top: 0; color: #cfe1d7; background: #18221d; }
:root .roi-expression-wide-table tbody th { color: #dce9e2; background: #111915; }

:root .roi-expression-wide-state {
  display: grid;
  justify-items: center;
  gap: 8px;
  min-height: 220px;
  place-content: center;
  padding: 24px;
  border: 1px solid #304238;
  border-radius: 12px;
  color: #b4c8bb;
  background: #101b14;
  font-size: 13px;
  text-align: center;
}

:root .roi-expression-wide-state.error { border-color: #754747; color: #ffd1d1; background: rgba(86, 28, 28, 0.2); }
:root .roi-expression-wide-state button { min-height: 34px; padding: 0 12px; border: 1px solid #875050; border-radius: 6px; color: #ffe9e9; background: #512b2b; cursor: pointer; }

:root .roi-expression-comparison-viewer {
  container-type: inline-size;
  position: absolute;
  z-index: 76;
  inset: auto 16px 16px;
  display: grid;
  grid-template-rows: auto minmax(0, 1fr);
  width: auto;
  min-width: 0;
  height: min(78%, 780px);
  min-height: 360px;
  max-height: calc(100% - 32px);
  overflow: hidden;
  border: 1px solid rgba(73, 102, 88, 0.96);
  border-radius: 14px;
  outline: none;
  color: #e8eee9;
  background: color-mix(in oklch, #0a110e 97%, transparent);
  box-shadow: 0 22px 56px rgba(0, 0, 0, 0.48);
  backdrop-filter: blur(20px);
  overscroll-behavior: contain;
  touch-action: auto;
  cursor: default;
  animation: roi-expression-viewer-in 180ms ease-out;
}

:root .roi-expression-comparison-viewer:focus-visible {
  outline: 3px solid rgba(100, 211, 168, 0.82);
  outline-offset: 2px;
}

:root .roi-expression-comparison-viewer.minimized {
  right: auto;
  grid-template-rows: auto;
  width: min(620px, calc(100% - 32px));
  height: auto;
  min-height: 0;
}

:root .roi-expression-comparison-viewer.maximized {
  inset: 12px;
  width: auto;
  height: auto;
  min-height: 0;
  max-height: none;
}

:root .app-shell[data-right-panel-open="true"] .roi-expression-comparison-viewer:not(.minimized) {
  right: calc(min(var(--right-panel-width, 360px), 380px) + 20px);
}

:root .app-shell[data-right-panel-open="true"] .roi-expression-comparison-viewer.maximized {
  right: calc(min(var(--right-panel-width, 360px), 380px) + 16px);
}

@media (min-width: 641px) {
  :root .app-shell[data-navigation-open="true"] .roi-expression-comparison-viewer:not(.minimized) {
    left: calc(
      var(--xw-floating-navigation-left, 10px)
      + var(--xw-floating-navigation-width, 184px)
      + var(--xw-floating-navigation-gap, 12px)
    );
  }
}

:root .roi-expression-viewer-header {
  position: relative;
  z-index: 20;
  display: grid;
  grid-template-columns: minmax(0, 1fr) auto auto;
  align-items: center;
  gap: 14px;
  min-height: 64px;
  padding: 10px 12px 10px 18px;
  border-bottom: 1px solid #2a3b33;
  background: #122019;
}

:root .roi-expression-comparison-viewer.minimized .roi-expression-viewer-header { border-bottom: 0; }

:root .roi-expression-comparison-viewer[data-window-draggable="true"] .roi-expression-viewer-header {
  cursor: grab;
  touch-action: none;
  user-select: none;
}

:root .roi-expression-comparison-viewer[data-window-dragging="true"] .roi-expression-viewer-header { cursor: grabbing; }
:root .roi-expression-viewer-header:focus-visible { outline: 2px solid #77d5b2; outline-offset: -3px; }

:root .roi-expression-comparison-viewer .roi-expression-wide-main,
:root .roi-expression-comparison-viewer .roi-expression-wide-results,
:root .roi-expression-comparison-viewer .roi-expression-wide-controls,
:root .roi-expression-comparison-viewer .roi-expression-wide-chart,
:root .roi-expression-comparison-viewer .roi-expression-wide-table { overscroll-behavior: contain; }

:root .roi-expression-viewer-heading {
  display: flex;
  min-width: 0;
  align-items: center;
  gap: 9px;
}

:root .roi-expression-viewer-heading > svg { flex: 0 0 auto; color: #67d2aa; }
:root .roi-expression-viewer-heading > span { display: grid; min-width: 0; gap: 2px; }
:root .roi-expression-viewer-heading small { color: #a1bcae; font-size: 10px; line-height: 1.3; }
:root .roi-expression-viewer-heading h2 { margin: 0; color: #eefaf3; font-size: 14px; line-height: 1.35; overflow-wrap: anywhere; }

:root .roi-expression-viewer-header-meta {
  display: inline-flex;
  min-width: 0;
  align-items: center;
  flex-wrap: wrap;
  gap: 6px;
}

:root .roi-expression-viewer-header-meta span {
  padding: 4px 7px;
  border: 1px solid #324f40;
  border-radius: 5px;
  color: #bcd3c7;
  background: rgba(13, 28, 22, 0.72);
  font-size: 10px;
  font-weight: 700;
  white-space: nowrap;
}

:root .roi-expression-viewer-actions {
  display: inline-flex;
  flex: 0 0 auto;
  gap: 5px;
}

:root .roi-expression-viewer-actions button {
  display: grid;
  width: 44px;
  min-width: 44px;
  height: 44px;
  place-items: center;
  padding: 0;
  border: 1px solid #385047;
  border-radius: 8px;
  color: #c9ddd3;
  background: rgba(14, 24, 20, 0.82);
  cursor: pointer;
}

:root .roi-expression-viewer-actions button:hover:not(:disabled) { border-color: #4b9c7c; color: #fff; background: #1b4537; }
:root .roi-expression-viewer-actions button:focus-visible { outline: 3px solid #77d5b2; outline-offset: 2px; }
:root .roi-expression-viewer-actions button:disabled { cursor: not-allowed; opacity: 0.4; }

:root .roi-expression-comparison-viewer .roi-expression-wide-summary { min-height: 50px; }
:root .roi-expression-comparison-viewer .roi-expression-wide-summary > span { padding: 6px 14px; }
:root .roi-expression-comparison-viewer .roi-expression-wide-summary strong { font-size: 13px; }
:root .roi-expression-comparison-viewer .roi-expression-wide-summary small { font-size: 8px; }

:root .roi-expression-comparison-viewer .roi-expression-wide-main {
  grid-template-columns: 238px minmax(0, 1fr);
  width: 100%;
  height: auto;
  min-height: 0;
  overflow: hidden;
}

:root .roi-expression-comparison-viewer .roi-expression-wide-controls { gap: 16px; padding: 18px 16px; }
:root .roi-expression-comparison-viewer .roi-expression-wide-results { gap: 14px; padding: 18px; }
:root .roi-expression-comparison-viewer .roi-expression-wide-chart .roi-expression-comparison-svg,
:root .roi-expression-comparison-viewer.maximized .roi-expression-wide-chart .roi-expression-comparison-svg { min-width: 820px; height: auto; max-height: none; }
:root .roi-expression-comparison-viewer .roi-expression-wide-state { min-height: 180px; }

@keyframes roi-expression-viewer-in {
  from { opacity: 0; }
  to { opacity: 1; }
}

@container (max-width: 1100px) {
  :root .roi-expression-viewer-header { grid-template-columns: minmax(0, 1fr) auto; gap: 8px 12px; }
  :root .roi-expression-viewer-header-meta { grid-column: 1 / -1; grid-row: 2; }
  :root .roi-expression-viewer-actions { grid-column: 2; grid-row: 1; }
  :root .roi-expression-comparison-viewer.minimized .roi-expression-viewer-header-meta { display: none; }
}

@container (max-width: 760px) {
  :root .roi-expression-comparison-viewer .roi-expression-wide-main {
    grid-template-columns: minmax(0, 1fr);
    height: auto;
    overflow-x: hidden;
    overflow-y: auto;
  }
  :root .roi-expression-comparison-viewer .roi-expression-wide-controls {
    grid-template-columns: repeat(2, minmax(0, 1fr));
    gap: 12px;
    overflow: visible;
    padding: 14px;
    border-right: 0;
    border-bottom: 1px solid #2a3831;
  }
  :root .roi-expression-wide-control-heading { grid-column: 1 / -1; }
  :root .roi-expression-wide-plot-switch { grid-column: 1 / -1; grid-template-columns: repeat(4, minmax(0, 1fr)); }
  :root .roi-expression-wide-gene-editor,
:root .roi-expression-wide-controls > p { grid-column: 1 / -1; }
  :root .roi-expression-comparison-viewer .roi-expression-wide-results { min-height: 0; overflow: visible; padding: 14px; }
}

@media (max-width: 820px) {
  :root .roi-expression-wide-workspace { min-height: 100dvh; overflow: auto; }
  :root .roi-expression-wide-workspace .roi-workspace-header h1 { max-width: 58vw; font-size: 14px; }
  :root .roi-expression-wide-summary { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  :root .roi-expression-wide-main { grid-template-columns: minmax(0, 1fr); height: auto; }
  :root .roi-expression-wide-controls { overflow: visible; border-right: 0; border-bottom: 1px solid #2a3831; }
  :root .roi-expression-wide-results { min-height: 0; overflow: visible; grid-auto-rows: max-content; }

  :root .roi-expression-comparison-viewer {
    inset: auto 8px 8px;
    height: min(88%, 820px);
    min-height: 320px;
    max-height: calc(100% - 16px);
    border-radius: 12px;
  }

  :root .roi-expression-comparison-viewer.maximized { inset: 8px; height: auto; max-height: none; }
  :root .roi-expression-comparison-viewer.minimized { right: 8px; width: auto; min-height: 0; }
  :root .roi-expression-viewer-header { grid-template-columns: minmax(0, 1fr) auto; gap: 8px; padding: 10px; }
  :root .roi-expression-viewer-header-meta { display: flex; grid-column: 1 / -1; grid-row: 2; }
  :root .roi-expression-comparison-viewer.minimized .roi-expression-viewer-header-meta { display: none; }
  :root .roi-expression-viewer-heading { gap: 7px; }
  :root .roi-expression-viewer-heading > svg { display: none; }
  :root .roi-expression-viewer-heading h2 { font-size: 12px; }
  :root .roi-expression-viewer-heading small { font-size: 9px; }
  :root .roi-expression-viewer-actions { grid-column: 2; grid-row: 1; gap: 3px; }
  :root .roi-expression-viewer-actions button { width: 40px; min-width: 40px; height: 40px; }
  :root .roi-expression-comparison-viewer .roi-expression-wide-main {
    grid-template-columns: minmax(0, 1fr);
    height: auto;
    min-height: 0;
    overflow-x: hidden;
    overflow-y: auto;
  }
  :root .roi-expression-comparison-viewer .roi-expression-wide-controls { overflow: visible; }
  :root .roi-expression-comparison-viewer .roi-expression-wide-results { min-height: 0; overflow: visible; }
}

@media (max-width: 980px) {
  :root .app-shell[data-right-panel-open="true"] .roi-expression-comparison-viewer:not(.minimized) { right: 8px; }
  :root .app-shell[data-right-panel-open="true"] .roi-expression-comparison-viewer.maximized { right: 8px; }
}

@media (max-width: 640px) {
  :root .app-shell.simplified-workspace-ui {
    --xw-bottom-navigation-clearance: calc(max(8px, env(safe-area-inset-bottom)) + 72px);
  }

  :root .roi-expression-comparison-viewer {
    bottom: var(--xw-bottom-navigation-clearance);
    min-height: 0;
    max-height: calc(100% - var(--xw-bottom-navigation-clearance) - 8px);
  }

  :root .roi-expression-comparison-viewer.maximized {
    bottom: var(--xw-bottom-navigation-clearance);
  }
}

@media (prefers-reduced-motion: reduce) {
  :root .roi-expression-open-workspace,
:root .roi-expression-wide-plot-switch button,
:root .roi-expression-wide-heatmap-switch button { transition-duration: 1ms; }
  :root .roi-expression-comparison-viewer { animation-duration: 1ms; }
}
/* Saved comparisons reuse the in-viewer controls in a regular page layout. */
:root .roi-expression-standalone { min-height: 100dvh; padding: 16px; background: #0b120e; color: #e8f0e9; }
:root .roi-expression-standalone > header { display: flex; gap: 16px; align-items: center; margin-bottom: 16px; }
:root .roi-expression-standalone > header a { color: #b5e8cc; }
:root .roi-expression-standalone .roi-expression-comparison-viewer { position: relative; inset: auto; width: 100%; max-width: none; height: auto; max-height: none; }

:root .roi-expression-feature-selector { display: grid; gap: 9px; min-width: 0; }
:root .roi-expression-feature-selector label,
:root .roi-expression-bulk-genes label { display: grid; gap: 5px; min-width: 0; font-size: 11px; color: #bdcec4; }
:root .roi-expression-feature-selector input,
:root .roi-expression-feature-selector select,
:root .roi-expression-feature-selector textarea,
:root .roi-expression-bulk-genes textarea { box-sizing: border-box; width: 100%; min-width: 0; padding: 8px; border: 1px solid #3b5144; border-radius: 7px; color: #e4efe8; background: #09140e; font: inherit; font-size: 11px; }
:root .roi-expression-feature-selector textarea,
:root .roi-expression-bulk-genes textarea { resize: vertical; max-height: 240px; }
:root .roi-expression-feature-mode { display: grid; grid-template-columns: 1fr 1fr; gap: 4px; padding: 4px; border: 1px solid #3b5144; border-radius: 8px; }
:root .roi-expression-feature-mode button { min-height: 34px; border: 1px solid transparent; border-radius: 6px; background: transparent; color: #c8d7cd; font-size: 11px; }
:root .roi-expression-feature-mode button.active { background: #205d47; border-color: #4e9c7d; color: white; }
:root .roi-expression-signature-definition { font-size: 10px; line-height: 1.5; color: #aebfb4; margin: 0; }
:root .roi-expression-feature-selector small { font-size: 10px; line-height: 1.45; color: #aebfb4; overflow-wrap: anywhere; }
:root .roi-expression-custom-signature,
:root .roi-expression-bulk-genes { display: grid; gap: 8px; font-size: 11px; }
:root .roi-expression-custom-signature > :not(summary),
:root .roi-expression-bulk-genes > :not(summary) { margin-top: 8px; }
:root .roi-expression-custom-signature summary,
:root .roi-expression-bulk-genes summary,
:root .roi-expression-signature-list summary { cursor: pointer; color: #d8e8df; overflow-wrap: anywhere; }
:root .roi-expression-signature-list { display: grid; gap: 7px; max-height: 280px; overflow-y: auto; overscroll-behavior: contain; }
:root .roi-expression-signature-list > div { display: flex; align-items: flex-start; gap: 6px; padding: 8px; border: 1px solid #3b5144; border-radius: 7px; font-size: 11px; }
:root .roi-expression-signature-list details { flex: 1; min-width: 0; }
:root .roi-expression-signature-list p { overflow-wrap: anywhere; font-size: 10px; }
:root .roi-expression-signature-list > div > button { flex: 0 0 26px; min-height: 26px; padding: 0; }
:root .roi-expression-gene-chips { max-height: 220px; overflow-y: auto; overscroll-behavior: contain; }
:root .roi-expression-signature-coverage { padding: 10px 12px; border: 1px solid #3b5144; border-radius: 8px; font-size: 11px; }
:root .roi-expression-signature-coverage summary { cursor: pointer; }
:root .roi-expression-signature-coverage > div { display: grid; gap: 3px; padding: 8px 0; border-top: 1px solid #2c3e32; overflow-wrap: anywhere; }

:root .roi-expression-statistics-control { display: grid; gap: 7px; padding: 10px; border: 1px solid #3b5144; border-radius: 8px; }
:root .roi-expression-statistics-control > label { display: flex; align-items: center; gap: 8px; cursor: pointer; color: #dcebe2; }
:root .roi-expression-statistics-control input[type="checkbox"] { flex: 0 0 16px; width: 16px; height: 16px; margin: 0; accent-color: #65c9a4; }
:root .roi-expression-statistics-control small { font-size: 10px; line-height: 1.5; color: #aebfb4; }
:root .roi-expression-statistics { min-width: 0; display: grid; gap: 10px; padding: 12px; border: 1px solid #3b5144; border-radius: 8px; color: #dcebe2; background: #0c1912; font-size: 11px; }
:root .roi-expression-statistics-heading { display: flex; flex-wrap: wrap; justify-content: space-between; align-items: center; gap: 8px; }
:root .roi-expression-statistics-heading > strong { font-size: 13px; }
:root .roi-expression-statistics-heading > span { font-size: 10px; color: #abc4b5; }
:root .roi-expression-statistics p { margin: 0; font-size: 11px; line-height: 1.55; }
:root .roi-expression-statistics-feature { font-size: 12px; overflow-wrap: anywhere; }
:root .roi-expression-statistics-omnibus { display: grid; gap: 5px; padding: 9px 10px; border-left: 3px solid #65c9a4; background: #15271d; }
:root .roi-expression-statistics-annotation-choice { display: grid; gap: 5px; min-width: 0; }
:root .roi-expression-statistics select { width: 100%; min-width: 0; max-width: 100%; padding: 8px; border: 1px solid #3b5144; border-radius: 7px; background: #09140e; color: #e4efe8; font: inherit; }
:root .roi-expression-statistics .roi-expression-wide-table { max-height: 360px; overflow: auto; overscroll-behavior: contain; }
:root .roi-expression-statistics th { white-space: normal; max-width: 270px; }
:root .roi-expression-statistics details { font-size: 11px; line-height: 1.55; }
:root .roi-expression-statistics details > :not(summary) { margin-top: 9px; }
:root .roi-expression-statistics details a { color: #84dfbd; }
:root .roi-expression-statistics details summary { cursor: pointer; }
:root .roi-comparison-export { display: flex; flex-wrap: wrap; gap: 7px; align-items: center; margin: 0; color: #b2c7b9; font-size: 11px; }
:root .roi-comparison-export button { min-height: 36px; padding: 6px 10px; border: 1px solid #36513f; border-radius: 6px; background: #14271b; color: #edf7ef; font-size: 11px; cursor: pointer; }
:root .roi-comparison-export button:hover:not(:disabled) { border-color: #61b38b; background: #1b3b29; }
:root .roi-comparison-export button:disabled { cursor: progress; opacity: .6; }
:root .roi-comparison-export button:focus-visible { outline: 2px solid #75dfa1; outline-offset: 3px; }